CRIS IL📊 Leads🔑 Keywords📋 Keyword Review📄 Papers🎤 Conference📬 Reports⚙ Config
A

Aaron Ciechanover

Medicine  ·  Technion
H-index: 105  ·  Citations: 57341  ·  Papers: 346
✉ not listed
View on CRIS ↗ ORCID ↗

Matched Keywords

neurodegenerative
Deprioritized:cellprotein

Research Areas (CRIS Fingerprint)

UbiquitinUbiquitin-proteasome SystemUbiquitinationUbiquitin SystemUbiquitin LigaseProtein DegradationCellular ProteinsConjugationLysosomeProteolytic CascadeProteasomal Degradation26S ProteasomeHuman DiseaseP105Ubiquitin-mediated DegradationIntracellular Protein DegradationProteolytic SystemNF-BDrug TargetDeubiquitinating EnzymeATP-dependentCellular ProcessesLigaseUbiquitination PathwayDisease TargetsMyoDTranscription FactorIntracellular ProteinPhosphorylationProteolysisTerminal ResidueAberrationsReticulocytesUbiquitin ChainsUbiquitin-activating Enzyme E1MalignancyNeurodegenerative DiseasesAutophagyProtein SubstrateTransfer RNA (tRNA)UbiquitinProteasomeUbiquitinationProtein CatabolismN-TerminusUbiquitin-Conjugating EnzymeUbiquitin LigaseLigaseEnzymeAdenosine TriphosphateCell CyclePrecursorMyoDLysineAutophagyC-TerminusAmino AcidsLysosomeTranscription FactorsProtease

Publications (45 linked — showing top 20)

Sera from Phylogenetically Related Alligators, Crocodiles and Domestic Chickens Exhibit Comparable Anti-Cancer Activity2026
Precise Mapping of the Proteasome Interaction Region (PIR) of p62/SQSTM1: Decoupling Condensate Formation from Proteasome Recruitment2026
Proteasomal proteolysis in p62 condensates directs tumor suppression or growth depending on their subcellular localization2026
Prevention of ubiquitination at K6 and K9 in mutant huntingtin exacerbates disease pathology in a knock-in mouse model2026
Regulation via compartmentation: adaptive localization of the proteasome under stress2025
Ubiquitin E3 ligase KPC1 governs mesenchymal metastatic melanoma reprogramming via proteasomal degradation of ZEB12025
Role of p62 nuclear condensates in regulating ubiquitin-mediated proteasomal degradation2025
Targeting degradation of IKZF1 and IKZF3 through modulation of the E3 ligase substrates in the context of cellular therapies for multiple myeloma2025
Discovery of a potent covalent inhibitor that unusually distorts the catalytic dyad of SARS-CoV-2 main protease2025
Bone Marrow-Targeted Liposomes Loaded with Bortezomib Overcome Multiple Myeloma Resistance2025
Protein quality control systems in neurodegeneration – culprits, mitigators, and solutions?2025
Vimentin is a ubiquitination and degradation substrate of the ubiquitin ligase KPC12025
CXCL12 restricts tumor growth by suppressing the Ras, ERK1/2, c-Myc, and the immune checkpoint PD-L1 pathways2024
Nuclear p62 condensates stabilize the promyelocytic leukemia nuclear bodies by sequestering their ubiquitin ligase RNF42024
Discovery of Novel Nonpeptidic Proteasome Inhibitors Using Covalent Virtual Screening and Biological Evaluation2024
Inhibition of nucleo-cytoplasmic proteasome translocation by the aromatic amino acids or silencing Sestrin3—their sensing mediator—is tumor suppressive2024
Peripheral sequestration of huntingtin delays neuronal death and depends on N-terminal ubiquitination2024
Reflections from Nobel laureates in chemistry2024
Personalized medicine: the future is here2024
Stress-Induced Proteasome Sub-Cellular Translocation in Cardiomyocytes Causes Altered Intracellular Calcium Handling and Arrhythmias2024